What is the Difference Between Semaglutide and Tirzepatide?

Semaglutide activates only GLP-1 receptors, while tirzepatide activates both GLP-1 and GIP receptors, making it a dual-action medication.

Semaglutide (brand names Ozempic, Wegovy): A GLP-1 receptor agonist that mimics a gut hormone to slow gastric emptying, increase fullness, and improve glucose metabolism. Clinical trials show about 15% body weight loss over two years.

Tirzepatide (brand name Mounjaro): A dual GLP-1/GIP receptor agonist with about 5× stronger GIP effects. It works similarly to semaglutide but with the added GIP action. Clinical trials show 15-21% body weight loss over 72 weeks, with some studies showing up to 26% loss.

Both are weekly injections used for weight loss and type 2 diabetes management. They share similar side effects (mainly gastrointestinal like nausea, vomiting, diarrhea) and similar contraindications.